Genome-wide Study Links Metabolic Changes With Early Onset of Alzheimer’s

Genome-wide Study Links Metabolic Changes With Early Onset of Alzheimer’s
March 14 , 2008 by Editor
PHOENIX, AZ - Researchers at the Translational Genomics Research Institute (TGen) and their colleagues today report a finding that correlates significant under-expression of genes in certain brain regions with the pattern of metabolic deficits in the brains of individuals with Alzheimer’s. The findings provide new information surrounding the development of Alzheimer's disease and identify novel targets to consider when developing methods to diagnose and treat the disease. The results appear on-line in the Early Edition of the Proceedings of the National Academy of Sciences.

Alzheimer's disease is an irreversible, progressive disorder in which certain brain cells (called neurons) deteriorate, resulting in the loss of cognitive functions including memory, judgment and reasoning, movement coordination, and pattern recognition. In advanced stages of the disease, all memory and mental functioning may be lost. The progressive neurological disorder afflicts an estimated five million Americans, a number expected to triple by 2050.



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